Sustained-release tablet composition of pramipexole

Details Sustained-release tablet composition of pramipexole Sustained-release tablet composition of pramipexole

A - Human Necessities

61

K

A61K 31/428 (2006.01) A61K 9/20 (2006.01) A61K 9/28 (2006.01) A61K 31/4745 (2006.01)

Patent

CA 2492854

A sustained-release pharmaceutical composition in a form of an orally deliverable tablet comprises a water-soluble salt of pramipexole, dispersed in a matrix comprising a hydrophilic polymer and a starch having a tensile strength of at least about 0.15 kN cm-2 at a solid fraction representative of a tablet.

L'invention concerne une composition pharmaceutique à libération prolongée se présentant sous la forme d'un comprimé oral comprenant un sel soluble dans l'eau de pramipexole, dispersé dans une matrice comprenant un copolymère hydrophile, et un amidon présentant une résistance à la traction d'au moins 0,15 kNcm?-2¿ environ, au niveau d'une fraction solide représentative du comprimé.

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