A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/22 (2006.01) A61J 3/00 (2006.01) A61K 9/00 (2006.01) A61K 31/4164 (2006.01) A61K 45/06 (2006.01) A61K 47/30 (2006.01) A61K 47/42 (2006.01) A61P 31/00 (2006.01) A61P 31/02 (2006.01) A61P 31/10 (2006.01) A61P 31/12 (2006.01) A61K 9/20 (2006.01)
Patent
CA 2455633
The invention concerns a sustained-release mucosal therapeutic bioadhesive system containing at least an active principle, exhibiting an active principle dissolution test higher than 70 % in 8 hours and the method for preparing same. Said therapeutic bioadhesive system comprises amounts of natural proteins representing at least 50 wt. % of active principle and at least 20 wt. % of said tablet, between 10 and 20 % of a hydrophilic polymer, compression excipients, and including between 4 and 10 % of an alkaline metal alkylsulphate to enhance local availability of the active principle and between 0.1 % and 1 % of a monohydrate sugar.
La présente invention est relative à un système thérapeutique bioadhésif mucosal à libération prolongée contenant au moins un principe actif, présentant un test de dissolution du principe actif supérieur a 70 % en 8 heures et à son procédé de préparation. Ledit système thérapeutique bioadhésif comprend des quantités de protéines naturelles représentant au moins 50% en poids de principe actif et au moins 20% en poids dudit comprimé, entre 10 et 20 % d'un polymère hydrophile, des excipients de compression, et comprenant entre 4 et 10 % d'un alkylsulfate d'un métal alcalin pour renforcer la disponibilité locale du principe actif et entre 0,1 % et 1 % d'un sucre monohydrate.
Aiache Jean-Marc
Chaumont Christine
Costantini Dominique
Bioalliance Pharma
Goudreau Gage Dubuc
LandOfFree
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