Sustained release therapeutic compositions based on high...

Details Sustained release therapeutic compositions based on high... Sustained release therapeutic compositions based on high...

A - Human Necessities

61

K

167/169

A61K 9/22 (2006.01) A61K 9/20 (2006.01) A61K 9/26 (2006.01)

Patent

CA 1188614

SUSTAINED RELEASE THERAPEUTIC COMPOSITIONS BASED ON HIGH MOLECULAR WEIGHT HYDROXYPROPYLMETHYLCELLULOSE ABSTRACT A carrier base material combined with a therapeutically active medicament and shaped and compressed to a solid unit dosage form having a regular and prolonged release pattern upon administration, the carrier base material being one or more hydroxypropylmethylcelluloses or a mixture of one or more hydroxypropylmethylcelluloses and up to 30% by weight of the mixture of methylcellulose, sodium carboxymethylcellulose and/or other cellulose ether, and wherein at least one of the hydroxypropylmethyl- celluloses has a methoxy content of 16-24 weight-%, a hydroxypropoxyl content of 4-32 weight-% and a number average molecular weight of at least 50,000 and wherein the carrier base material constitutes less than about one third of the weight of the solid unit dosage form.

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