Sustained-release tramadol formulations with 24-hour...

A - Human Necessities – 61 – K

Patent

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A61K 31/137 (2006.01)

Patent

CA 2702138

There is disclosed a once daily oral pharmaceutical compositon for controlled release of tramadol or a salt thereof, wherein the composition, when ingested orally, provides a clinical effect over 24 hours which is a least as good as the clinical effect over 24 hours of two doses of a twice daily oral pharmaceutical composition for controlled release of tramadol, taken 12 hours apart.

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