Swellable (meth)acrylate surfaces for culturing cells in...

C - Chemistry – Metallurgy – 12 – N

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C12N 5/00 (2006.01)

Patent

CA 2750933

Synthetic surfaces capable of supporting culture of undifferentiated human embryonic stem cells in a chemically defined medium include a swellable (meth)acrylate layer and a peptide conjugated to the swellable (meth)acrylate layer. The swellable (meth)acrylate layer may be formed by polymerizing monomers in a composition that includes hydroxyethyl methacrylate, 2-carboxyehylacrylate, and tetra(ethylene glycol) dimethacrylate. The conjugated peptide may include an amino acid sequence of XaanProGlnValThrArgGlyAspValPheThrMetPro, where n is an integer from 0 to 3 and where Xaa is any amino acid. Further, disclosed herein is a swellable (meth)acrylate synthetic surface which can be sterilized by gamma irradiation.

L'invention concerne des surfaces synthétiques permettant de cultiver des cellules souches embryonnaires humaines indifférenciées dans un milieu chimiquement défini, qui comprennent une couche de (méth)acrylate pouvant gonfler et un peptide conjugué à la couche de (méth)acrylate. La couche de (méth)acrylate pouvant gonfler est formée par la polymérisation de monomères dans une composition qui comprend de l'hydroxyéthyl méthacrylate, du 2-carboxyéthylacrylate et du diméthacrylate de tétraéthylène glycol. Le peptide conjugué comprend une séquence d'acides aminés de XaanProGlnValThrArgGlyAspValPheThrMetPro, n représentant un nombre entier compris entre 0 et 3, et Xaa représentant n'importe quel acide aminé. De plus, l'invention concerne une surface synthétique de (méth)acrylate pouvant gonfler et qui peut être stérilisée par irradiation aux rayons gamma.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Swellable (meth)acrylate surfaces for culturing cells in... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Swellable (meth)acrylate surfaces for culturing cells in..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Swellable (meth)acrylate surfaces for culturing cells in... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1893409

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.