Symmetric, monofunctionalised polymethine dyes labelling...

C - Chemistry – Metallurgy – 09 – B

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C09B 23/12 (2006.01) C09B 23/00 (2006.01) C09B 23/01 (2006.01) C09B 23/02 (2006.01) C09B 23/06 (2006.01) C09B 23/08 (2006.01) G01N 33/533 (2006.01)

Patent

CA 2366255

A symmetric cyanine of the formula: (see formula I) wherein: X is selected from the group consisting of O, S and C(CH3)2: W represents non-metal atoms required to form a benzo-condensed or a naphto-condensed ring; R1 is selected from the group consisting of (CH2)n CH3, (CH2)n SO3- and (CH2)n SO3H, wherein n is an integer selected from 0 to 6 when R1 is (CH2)n CH3, and n is an integer selected from 3 to 6 when R1 is (CH2)n SO3- or (CH2)n SO3H; R2 and R3 are independently selected from the group consisting of H, a sulphonic moiety and a sulphonate moiety; Q is selected from the group consisting of: (see formula II) (see formula I) wherein q is 0 or 1 and D is selected from the group consisting of: -C.ident.C-G; and (see formulas II, III, IV) wherein A is O or S and G is, or contains a N, O or S nucleophile moiety or is, or contains a moiety capable of reacting with N, O or S nucleophiles.

Divulgation d'une cyanine symétrique de formule : (voir la formule I), dans laquelle : X est choisi parmi le groupe composé de O, S et C(CH3)2; W représente des atomes non métalliques requis pour former un cycle benzo-condensé ou naphto-condensé; R1 est choisi parmi le groupe composé de (CH2)n CH3, (CH2)n SO3- et (CH2)n SO3H, n étant un nombre entier de 0 à 6 quand R1 est (CH2)n CH3 et n est un nombre entier de 3 à 6 quand R1 est (CH2)n SO3- ou (CH2)n SO3H; R2 et R3 sont choisis de manière indépendante parmi le groupe composé de H, une entité sulfonique et une entité sulfonate; Q est choisi parmi le groupe composé de (voir la formule II) (voir la formule I) dans lesquelles q est 0 ou 1 et D est choisi parmi le groupe composé de -C.ident.C-G; et (voir les formules II, III, IV) dans lesquelles A est O ou S et G est ou contient une entité nucléophile N, O ou S ou est ou contient une entité capable de réagir avec des nucléophiles N, O ouS.

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