C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 69/00 (2006.01) A61K 31/166 (2006.01) A61K 31/235 (2006.01) A61P 1/00 (2006.01) A61P 3/00 (2006.01) A61P 9/00 (2006.01) C07C 225/16 (2006.01) C07C 233/65 (2006.01) C07C 233/66 (2006.01) C07C 233/69 (2006.01) C07C 233/73 (2006.01) C07C 255/46 (2006.01) C07C 311/46 (2006.01) C07D 207/325 (2006.01) C07D 213/30 (2006.01) C07D 213/40 (2006.01) C07D 295/12 (2006.01) C07D 295/13 (2006.01) C07D 295/18 (2006.01) C07D 295/192 (2006.01) C07D 311/82 (2006.01) C07D 311/86 (2006.01) C07D 327/08 (2006.01) C07D 411/12
Patent
CA 2434636
Symmetrically disubstituted aromatic compounds and pharmaceutical compositions containing such compounds that inhibit and/or modulate the activity of poly(ADP-ribose) glycohydrolase, also known as PARG, are described. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds.
L'invention concerne des composés aromatiques symétriquement disubstitués et des compositions pharmaceutiques contenant de tels composés inhibant et/ou modulant l'activité de la poly(ADP-ribose) glycohydrolase, également connue sous le nom de PARG. Cette invention concerne également l'utilisation à des fins thérapeutiques ou prophylactiques de ces composés et de ces compositions, ainsi que des méthodes permettant de traiter des maladies et des troubles décrits dans cette invention, qui consiste à administrer des quantités efficaces de ces composés.
Ferraris Dana V.
Kletzly Paul W.
Li Jia-He
Li Weixing
Wang Eric Yanjun
Goudreau Gage Dubuc
Guilford Pharmaceuticals Inc.
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