Synaptic vesicle cycling assays and systems

C - Chemistry – Metallurgy – 12 – Q

Patent

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Details

C12Q 1/02 (2006.01) C12M 1/34 (2006.01) C12M 1/42 (2006.01) G01N 33/48 (2006.01) C12N 5/079 (2010.01)

Patent

CA 2744804

The present invention provides, in part, platforms for analyzing an aspect of synaptic vesicle cycling. According to other aspects, the invention provides neuronal cell culture platform and platforms for analyzing an aspect of synaptic vesicle cy-cling. According to other aspects, the invention provides methods of measuring an aspect of synaptic vesicle cycling in a plurality of cells. According to other aspects, the invention provides methods for identifying a test agent as a modulator of an aspect of synaptic vesicle cycling.

La présente invention concerne, en partie, des plates-formes pour analyser un aspect du cyclage de vésicules synaptiques. Selon d'autres aspects, l'invention concerne une plate-forme de culture de cellules neuronales et des plates-formes pour analyser un aspect du cyclage de vésicules synaptiques. Selon d'autres aspects, l'invention concerne des procédés de mesure d'un aspect du cyclage de vésicules synaptiques dans une pluralité de cellules. Selon d'autres aspects, l'invention concerne des procédés pour identifier un agent d'essai en tant que modulateur d'un aspect du cyclage de vésicules synaptiques.

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