Synergic combinations comprising a quinoline compound and...

Details Synergic combinations comprising a quinoline compound and... Synergic combinations comprising a quinoline compound and...

A - Human Necessities

61

K

A61K 31/47 (2006.01) A61K 31/402 (2006.01) A61K 31/506 (2006.01) A61K 31/551 (2006.01) A61P 31/18 (2006.01) C07D 215/48 (2006.01)

Patent

CA 2610029

The invention relates to a combination comprising a quinoline compound or its salt, according to general formula (I) and at least one HIV infection therapeutic agent selected from the group consisting of entry inhibitors, reverse-transcriptase inhibitors, strand-transfer inhibitors, protease inhibitors, and maturation inhibitors. Said combination has therapeutic synergy in the treatment of an HIV infection compared with the quinoline compound, or HIV infection therapeutic agent alone.

L'invention concerne une combinaison comprenant un composé de quinoléine ou un sel de celle-ci, selon la formule générale (I) et au moins un agent thérapeutique contre une infection au VIH sélectionné dans le groupe comprenant : des inhibiteurs d'entrée, des inhibiteurs de la transcriptase inverse, des inhibiteurs de transfert de brins, des inhibiteurs de la protéase et des inhibiteurs de maturation. La combinaison présente une synergie thérapeutique dans le traitement d'une infection au VIH comparativement au composé de quinoléine ou à un agent thérapeutique contre une infection au VIH seul.

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