Synergistic agents

Details Synergistic agents Synergistic agents

A - Human Necessities

61

K

A61K 31/47 (2006.01) A61K 31/35 (2006.01) A61K 31/405 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01)

Patent

CA 2054312

A B S T R A C T SYNERGISTIC AGENTS The invention relates to synergistic agents for the treatment of inflammatory or arthritic conditions which comprise one of a selected group of inhibitors of the enzyme 5-lipoxygenase in conjunction or admixture with an inhibitor of the enzyme cyclooxygenase. Conveniently the 5-lipoxygenase inhibitor is, for example, 6-[(3-fluoro-5-[4-methoxy-3,4,5,6-tetrahydro-2H- pyran-4-yl]phenoxy)methyl]-1-methyl-2-quinolone or 4-[5-fluoro- 3-(4-methyl-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-7-ylthio)phenyl]- 4-methoxytetrahydropyran and the cyclooxygenase inhibitor is selected from indomethacin, flurbiprofen and diclofenac. The invention also relates to a pharmaceutical composition containing said synergistic agent and to the use of said agent in the manufacture of a medicament for the synergistic treatment of inflammatory or arthritic disease.

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