A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4188 (2006.01) A61K 31/407 (2006.01) A61K 31/417 (2006.01) A61K 31/53 (2006.01) A61K 31/7068 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2548491
The present invention provides compositions and methods useful in treating cancer which include a synergistic combination of an antineoplastic thiol- binding mitochondrial oxidant with an antineoplastic nucleic acid binding agent, an antineoplastic antimetabolite base analog, or docetaxel. Fig. 1 is a representation of combinations index data for imexon in combination which cisplatin, dacarbazine (DTIC), melphlan or taxotere in A375 cells.
L'invention concerne des compositions utiles dans le traitement du cancer. Ces compositions comprennent une combinaison d'un oxydant mitochondrial antinéoplasique fixant le thiol avec un agent antinéoplasique fixant l'acide nucléique, un analogue antinéoplasique à base antimétabolique ou du docétaxel. L'invention porte également sur des méthodes de dosage des effets synergiques des combinaisons et méthodes de traitement du cancer au moyen des combinaisons synergiques de l'invention.
Alberts David S.
Dorr Robert T.
Hersh Evan M.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
The Arizona Board Of Regents On Behalf Of The University Of Ariz
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