C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/86 (2006.01)
Patent
CA 2561245
The present invention broadly relates to the synergistic attenuation of vesicular stornatitis virus (VSV). More particularly, the invention relates to the identification of combined mutation classes which synergistically attenuate the pathogenicitnof VSV vectors in mammals and imrPWnogenic compositions thereof.
Au sens large, l'invention concerne l'affaiblissement par effet de synergie du VSV, et plus particulièrement l'identification des classes de mutation combinées qui affaiblissent par effet de synergie le caractère pathogène des vecteurs de ce virus chez le mammifère, et elle concerne enfin des compositions immunogènes correspondantes.
Clarke David Kirkwood
Hendry Roger Michael
Parks Christopher Lee
Udem Stephen A.
Torys Llp
Wyeth
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