Synergistic combination for the treatment of pain...

Details Synergistic combination for the treatment of pain... Synergistic combination for the treatment of pain...

A - Human Necessities

61

K

A61K 31/517 (2006.01) A61K 31/135 (2006.01) A61K 31/4468 (2006.01) A61K 31/485 (2006.01) A61P 25/04 (2006.01)

Patent

CA 2614528

The invention relates to a pharmaceutical dosage form comprising an analgesic combination for simultaneous or sequential use which comprises a peripherally restricted cannabinoid CB1 receptor agonist having a brain Cmax to plasma Cmax ratio of less than 0.1 and an opioid receptor agonist, as well as to a method for treating pain using said pharmaceutical dosage form.

L'invention concerne une forme dosifiée pharmaceutique comprenant une combinaison analgésique destinée à une utilisation simultanée ou séquentielle. Cette forme dosifiée comprend un agoniste du récepteur canabinoïde CB1 périphériquement restreint présentant un rapport C<SUB>max</SUB> cerveau sur C<SUB>max</SUB> plasma inférieur à 0,1, et un agoniste du récepteur opioïde. L'invention concerne également une méthode pour traiter un douleur à l'aide de cette forme dosifiée pharmaceutique.

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