Synergistic combinations

Details Synergistic combinations Synergistic combinations

A - Human Necessities

61

K

A61K 31/53 (2006.01) A61K 31/195 (2006.01) A61K 31/197 (2006.01) A61K 31/20 (2006.01) A61K 31/41 (2006.01) A61K 31/4245 (2006.01) A61K 31/4985 (2006.01) A61K 31/519 (2006.01) A61K 31/522 (2006.01) A61P 25/00 (2006.01) A61P 25/02 (2006.01)

Patent

CA 2495433

The instant invention relates to a combination of an alpha-2-delta ligand and a PDEV inhibitor for use in therapy, particularly in the curative, prophylactic or palliative treatment of pain, particularly neuropathic pain. Particularly preferred alpha-2-delta ligands are gabapentin and pregabalin. Particularly preferred PDEV inhibitors are sildenafil, vardenafil and tadalafil.

L'invention concerne une combinaison d'un ligand alpha-2-delta et d'un inhibiteur de PDEV utilisée à des fins thérapeutiques, en particulier dans le traitement, la prévention ou le traitement palliatif de la douleur, notamment la douleur neuropathique. Les ligands alpha-2-delta particulièrement préférés sont la gabapentine et la prégabaline. Les inhibiteurs de PDEV particulièrement préférés sont le sildenafil, le vardenafil et le tadalafil.

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