Synergistic combinations including n-acylated...

Details Synergistic combinations including n-acylated... Synergistic combinations including n-acylated...

A - Human Necessities

61

K

A61K 31/428 (2006.01) A61K 31/485 (2006.01) A61K 31/522 (2006.01) A61P 25/04 (2006.01)

Patent

CA 2531829

The present invention relates to pharmaceutical combinations of opioid and non- opioid analgesics in an intimate admixture with caffeine and an analgesic from a series of N-acylated 4-hydroxyphenylamine derivatives, linked via an alkylene bridge to the nitrogen atom of a 1, 2-benzisothiazol-3 (2H)-one 1, 1- dioxide group and methods for their use to alleviate pain in mammals. The analgesic combinations exhibit enhanced analgesic potency and are free from antipyretic activity, do not suppress blood coagulation, and have little hepatotoxic effect.

L'invention concerne des combinaisons pharmaceutiques d'analgésiques opioïdes et non opioïdes dans un mélange intime avec de la caféine et un analgésique d'une série de dérivés de 4-hydroxyphénylamines N-acylées, liés par un pont alkylène à l'atome d'azote d'une groupe de 1,2-benzisothiazol-3(2H)-one 1,1-dioxyde. L'invention concerne également des procédés permettant d'utiliser ces combinaisons en vue d'alléger la souffrance chez les mammifères. Lesdites combinaisons analgésiques présentent une meilleure capacité analgésique, n'ont pas d'activité antipyrétique, ne suppriment pas la coagulation sanguine et n'ont guère d'effets hépatoxiques.

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