C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 63/06 (2006.01) A61K 31/19 (2006.01) A61K 31/192 (2006.01) A61K 31/335 (2006.01) A61K 31/337 (2006.01) A61K 38/17 (2006.01) A61K 47/12 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2441335
Chemotherapeutic combinations of selected cytotoxic agents and RAR alpha/beta selective agonists (see Figure 1) or RAR pan antagonists (see Figure 2) for use in treating cancer and lowering the effective cytotoxic dose of the selected cytotoxic agent are provided.
La présente invention concerne des combinaisons chimiothérapiques d'agents cytotoxiques et d'agonistes sélectifs des RAR.alpha./.beta. ou des antagonistes de l'ensemble des RAR à utiliser pour le traitement du cancer et pour abaisser la dose cytotoxique effective de l'agent cytotoxique sélectionné.
Gottardis Marco M.
Lorenzi Matthew V.
Vivat-Hannah Valerie Sandrine
Zusi Fred Christopher
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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