A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/428 (2006.01) A61K 31/485 (2006.01) A61K 45/06 (2006.01) A61P 25/04 (2006.01)
Patent
CA 2509252
The present invention relates to pharmaceutical combinations of opioid and non- opioid analgesics in an intimate admixture with an analgesic from a series of N-acylated 4-hydroxyphenylamine derivatives, linked via an alkylene bridge to the nitrogen atom of a 1,2-benzisothiazol-3 (2H) -one 1, 1-dioxide group and methods for their use to alleviate pain in mammals. The analgesic combinations exhibit enhanced analgesic potency, do not suppress blood coagulation, and have little hepatotoxic effect.
L'invention concerne des combinaisons pharmaceutiques d'analgésiques opioïdes et non opioïdes, en mélange intime avec un analgésique d'une série de dérivés de 4-hydroxyphénylamines N-acylées, liés par un pont alkylène à l'atome d'azote d'un groupe 1,2-benzisothiazol-3(2H)-one 1,1-dioxyde. L'invention concerne également des méthodes permettant d'utiliser lesdites combinaisons pour alléger la souffrance de mammifères. Lesdits combinaisons analgésiques présentent une capacité analgésique améliorée, n'altèrent pas la coagulation sanguine et ont des effets hépatotoxiques réduits.
Alvarez-Builla Julio
Bazan Nicolas G.
Paul Dennis
Sunkel Carlos
Board Of Supervisors Of Louisiana State University And Agricultu
Lsu Medical Center Foundation
Mccarthy Tetrault Llp
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