Synergistic composition comprising rapamycin and calcitriol

Details Synergistic composition comprising rapamycin and calcitriol Synergistic composition comprising rapamycin and calcitriol

A - Human Necessities

61

K

A61K 31/435 (2006.01) A61K 31/045 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2270373

This invention provides a combination of rapamycin and 1,25-dihydroxy- cholecalciferol (1,25(OH)2D3) which is useful for inducing immunosuppression, and in the treatment of transplantation rejection, graft vs. host disease, autoimmune diseases, diseases of inflammation, adult T-cell leukemia/lymphoma, neoplasms, fungal infections, and hyperproliferative vascular disorders.

Cette invention a trait à une combinaison de rapamycine et de 1,25-dihydroxy-cholecalciférol (1,25(OH)¿2?D¿3?) efficace s'agissant de provoquer une immuno-dépression ainsi que pour traiter un rejet de transplantation, transplant c. maladie-hôte, des maladies auto-immunes, des maladies inflammatoires, une leucémie et/ou un lymphome T chez l'adulte, des néoplasmes, des mycoses ainsi que des troubles vasculaires hyperprolifératifs.

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