C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 31/395 (2006.01) A61K 31/403 (2006.01) A61K 31/438 (2006.01) A61K 31/5355 (2006.01) A61K 39/42 (2006.01) A61K 45/06 (2006.01) A61P 31/18 (2006.01) C12N 5/20 (2006.01)
Patent
CA 2637463
Synergistic pharmaceutical compositions for treating or preventing HIV-1 infections comprising anti-CCR5 monoclonal antibodies and CCR5 antagonists, viral fusion inhibitors or viral attachment inhibitors are disclosed. The compositions exhibit significant greater activity than is anticipated from the activity of either component alone. Also provided are methods for treating or preventing HIV-1 using the same.
L'invention concerne des compositions pharmaceutiques synergiques destinées au traitement ou à la prévention d'infections par le VIH-1, comprenant des anticorps monoclonaux anti-CCR5 et des antagonistes CCR5, des inhibiteurs de fusion virale ou des inhibiteurs de fixation virale. Ces compositions présentent une activité sensiblement supérieure à celle de chaque composant utilisé seul. L'invention concerne également des méthodes destinées au traitement ou à la prévention du VIH-1, dans lesquelles sont utilisées ces compositions.
Ji Changhua
Sankuratri Suryanarayana
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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