A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/18 (2006.01) C12N 5/079 (2010.01) C07K 14/51 (2006.01)
Patent
CA 2303460
A synergistic effect of OP/BMP morphogens in combination with GDNF/NGF neurotrophic factors in promoting the survival or growth, or inhibiting the death or degeneration, of mammalian cells, particularly neural cells, which express OP/BMP-activated serine/threonine kinase receptors and GDNF/NGF- activated tyrosine kinase receptors, is disclosed. Also disclosed are new methods for the in vivo and in vitro treatment of such cells, including in vivo treatments for mammals afflicted with, or at imminent risk of, damage or injury to such cells, as well as new pharmaceutical preparations for such in vivo and in vitro treatments.
La présente invention concerne un effet synergique de morphogènes OP/BMP combinés avec des facteurs neurotropes GDNF/NGF permettant de promouvoir la survie ou la croissance, ou l'inhibition de la mort ou de la dégénérescence de cellules de mammifères, notamment des cellules neurales qui expriment des récepteurs de la sérine/thréonine kinase activés par OP/BMP et des récepteurs de la tyrosine kinase activés par GDNF/NGF. La présente invention concerne également de nouveaux procédés de traitement in vivo et in vitro de ces cellules, notamment des traitements in vivo pour des mammifères souffrant ou présentant un risque imminent de lésion ou de blessure de ces cellules ainsi que de nouvelles préparations pharmaceutiques pour ces traitements in vivo et in vitro.
Charette Marc F.
Ebendal Ted
Rueger David C.
Creative Biomolecules Inc.
Mbm Intellectual Property Law Llp
Stryker Corporation
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