Synergistic use of thiazolidinediones with glucagon-like...

Details Synergistic use of thiazolidinediones with glucagon-like... Synergistic use of thiazolidinediones with glucagon-like...

A - Human Necessities

61

K

A61K 38/00 (2006.01) A61K 38/22 (2006.01) A61K 38/26 (2006.01)

Patent

CA 2349865

Thiazolidinedione (TZD) and its pharmacologically active derivatives can be used, in combination with agonists of glucagon-like peptide-1 (GLP-1), to treat non-insulin dependent diabetes mellitus, optionally with other therapies, by improving glycemic control while minimizing side effects, such as heart hypertrophy and elevated fed-state plasma glucose, which are associated with both TZD and GLP-1 monotherapies. Thus, the co-administration of TZD and GLP-1 helps regulate glucose homeostasis in Type II diabetic patients.

Le thiazolidinédione (TZD) et ses dérivés pharmacologiquement actifs peuvent être utilisés en association avec des agonistes de peptide 1 de type glucagone (GLP-1) pour traiter le diabète non insulino-dépendant, éventuellement avec d'autres thérapies, en améliorant le contrôle glycémique tout en réduisants les effets secondaires, comme l'hypertrophie cardiaque et un taux de glucose plasmatique élevé dans un état alimenté qui sont associées aux deux monothérapies par TZD et GLP-1. Ainsi, l'administration combinée de TZD et GLP-1 favorise la régulation de l'homéostase de glucose chez les patients souffrant de diabète de type II.

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