Synthesis

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 257/02 (2006.01)

Patent

CA 2604219

The invention relates to an improved process for preparation of protected DO3A, such as DO3A-tri-t-butyl ester (1,4,7,10-tetraazacyclododecane-1,4,7- triacetic acid tri-t-butyl ester). The compound is prepared as a salt. The process includes a work-up procedure giving DO3A-tri-t-butyl ester as a salt of excellent purity.

La présente invention concerne un procédé amélioré de synthèse d'un dérivé de DO3A protégé, tel que l'ester de tri-t-butyle de DO3A (1,4,7,10-tétraazacyclododécane-1,4,7-triacétate de tri-t-butyle). Le composé est préparé sous forme d~un sel. Le procédé inclut une procédure de traitement permettant d'obtenir l'ester de tri-t-butyle de DO3A sous forme d'un sel de pureté très élevée.

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