C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 261/08 (2006.01) A61K 31/42 (2006.01) A61P 33/02 (2006.01)
Patent
CA 2545778
Novel dicationic 3,5-diphenylisoxazole compounds are described. Synthetic routes to these novel compounds are provided. Several of the compounds displayed in vitro activity versus Trypanosoma brucei brucei and Plasmodium falciparum comparable to that of furamidine. A majority of the novel compounds also were less toxic to VERO cells than furamidine.
Bakunov Stanislav A.
Bakunova Svetlana M.
Patrick Donald A.
Tidwell Richard R.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
The University Of North Carolina At Chapel Hill
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