Synthesis and application of high molecular weight...

Details Synthesis and application of high molecular weight... Synthesis and application of high molecular weight...

C - Chemistry, Metallurgy

08

G

402/301

C08G 67/04 (2006.01)

Patent

CA 1274339

SYNTHESIS AND APPLICATION OF HIGH MOLECULAR WEIGHT POLYANHYDRIDES Abstract of the Disclosure High molecular weight polyanhydrides, defined as polyanhydrides having a molecular weight average greater than 20,000 or an intrinsic viscosity of greater than 0.3 dl/g in an organic solvent at room temperature, are formed by melt polycondensation of highly pure isolated prepolymers under optimized reaction conditions, particularly time and temperature with removal of the condensation product. Higher molecular weights are obtained by inclusion of a catalyst with the prepolymers in the melt polymerization. Catalysts used for transterfication, ring opening polymerization and related polymerizations may be utilized. The high molecular weight polyanhydrides have improved physico-mechanical properties and are especially well suited for biomedical applications, particularly in controlled release devices for drug delivery. -1-

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