C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/10 (2006.01) A61K 31/4245 (2006.01) A61P 25/00 (2006.01) C07D 271/113 (2006.01)
Patent
CA 2703465
The present invention relates to a process for producing crystalline 3-[(1S)-1- (1-{(S)-(4-chlorophenyl)[3-(5-oxo- 4,5-dihydro-1,3,4-oxadiazol-2-yl)phenyl]methyl} azetidin-3-yl)-2-fluoro-2- methylpropyl]-5-fluorobenzonitrile, and novel salts, solvates, hydrates and polymorphs thereof.
La présente invention concerne un procédé de production de 3-[(1S)-1-(1-{(S)-(4-chlorophényl)[3-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)phényl]méthyl} azétidin-3-yl)-2-fluoro-2-méthylpropyl]-5-fluorobenzonitrile cristallin, et de nouveaux sels, solvates, hydrates et polymorphes de celui-ci.
Campos Kevin R.
Chen Cheng-Yi
Foley Jennifer R.
Hillier Michael
Jen Wendy S.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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