Synthesis and crystalline forms of cb-1 antagonist/inverse...

C - Chemistry – Metallurgy – 07 – D

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C07D 413/10 (2006.01) A61K 31/4245 (2006.01) A61P 25/00 (2006.01) C07D 271/113 (2006.01)

Patent

CA 2703465

The present invention relates to a process for producing crystalline 3-[(1S)-1- (1-{(S)-(4-chlorophenyl)[3-(5-oxo- 4,5-dihydro-1,3,4-oxadiazol-2-yl)phenyl]methyl} azetidin-3-yl)-2-fluoro-2- methylpropyl]-5-fluorobenzonitrile, and novel salts, solvates, hydrates and polymorphs thereof.

La présente invention concerne un procédé de production de 3-[(1S)-1-(1-{(S)-(4-chlorophényl)[3-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)phényl]méthyl} azétidin-3-yl)-2-fluoro-2-méthylpropyl]-5-fluorobenzonitrile cristallin, et de nouveaux sels, solvates, hydrates et polymorphes de celui-ci.

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