C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/58 (2006.01) A61K 31/4468 (2006.01) A61P 7/02 (2006.01) A61P 25/00 (2006.01)
Patent
CA 2580136
Disclosed herein are methods for synthesizing N-(4-fluorobenzyl -N-(I- methylpiperidin~)4-yl)-N'-(442-methylpropyloxy)-phenylmethyl)carbamide, Formula (I). Also disclosed herein is the hemi~tartrate salt of N-(4- fluorobenzyl)-N-(I-methylpiperidin-4-yl)-N'-(4-(2- methylpropyloxy)~phenylmethyl)carbamide and methods for obtaining the salt. Further disclosed are various crystalline forms of N-(4-fluorobenzyl)-N-(I- methylpiperidin-4-yl)-N'-(4-(2-metylpropyloxy)-phenymethyl)carbamide and its hemi-tartrate salt including various polymorphs and solvates.
L'invention concerne des procédés de synthèse du N-(4-fluorobenzyl)-N-(1-méthylpipéridin-)4-yl)-N'-(4-(2-méthylpropyloxy)-phénylméthyl)carbamide représenté par la formule (I). L'invention concerne aussi l'hémitartrate de N-(4-fluorobenzyl)-N-(I-méthylpipéridin-4-yl)-N'-(4-(2-méthylpropyloxy)-phénylméthyl)carbamide et des procédés d'obtention de ce sel. L'invention concerne en outre diverses formes cristallines de N-(4-fluorobenzyl)-N-(1-méthylpipéridin-4-yl)-N'-(4-(2-méthylpropyloxy)-phényméthyl)carbamide et l'hémitartrate de ce composé, y compris divers polymorphes et solvates.
Andersson Carl-Magnus A.
Berghausen Jorg
Blatter Fritz
Schlienger Nathalie
Thygesen Mikkel
Acadia Pharmaceuticals Inc.
Smart & Biggar
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