C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
C07J 41/00 (2006.01) C07J 1/00 (2006.01)
Patent
CA 2187522
17.beta.-Cyano-3,17.alpha.-dihydroxy-6-methylandrosta-3,5,9(11)-triene 3-ethyl ether (II) is prepared by reacting 3-hydroxy-6-methylandrosta- 3,5,9(11)-trien-17-one 3- ethyl ether (I) with hydrogen cyanide at a pH of about 7 to about 11. The product is a useful intermediate in the production of pharmacologically active steroids including methylprednisolone.
On prépare l'éther 17.beta.-cyano-3,17.alpha.-dihydroxy-6-méthylandrosta-3,5,9(11)-triène-3-éthylique (II) en faisant réagir l'éther 3-hydroxy-6-méthylandrosta-3,5,9(11)-triène-17-one 3-éthylique (I) avec du cyanure d'hydrogène à un pH dans la plage allant d'environ 7 à environ 11. Le produit est un intermédiaire utile dans la production de stéroïdes actifs du point de vue pharmacologique, en particulier de la méthylprednisolone.
Debiak-Krook Therese
Reid John Gregory
Macrae & Co.
Pharmacia & Upjohn Company
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