Synthesis of 2' ,3'-dideoxycytidine

Details Synthesis of 2' ,3'-dideoxycytidine Synthesis of 2' ,3'-dideoxycytidine

C - Chemistry, Metallurgy

07

H

260/229.4

C07H 19/067 (2006.01)

Patent

CA 1332942

2',3'-Dideoxycytidine is prepared by subjecting an N-acyl-3'-halo-2'-acylcytidine to a reductive elimination reaction using a zinc-copper couple followed by reduction and removal of protecting groups. The N-acyl-3'-halo-2'-acylcytidine can be obtained by reacting N-acyl cytidine with a suitable halogenating agent, for example 2-acetoxy-isobutyryl bromide. 2'3'-Dideoxy- cytidine is used in processes of oligo-nucleotide sequencing and is of interest for treatment of AIDS and AIDS-related diseases.

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