Synthesis of 2-amino-2-deoxyglycoses and 2-amino-2-...

Details Synthesis of 2-amino-2-deoxyglycoses and 2-amino-2-... Synthesis of 2-amino-2-deoxyglycoses and 2-amino-2-...

C - Chemistry, Metallurgy

07

H

260/227

C07H 5/04 (2006.01)

Patent

CA 1111418

"SYNTHESIS OF 2-AMINO-2-DEOXYGLYCOSES AND 2-AMINO-2-DEOXYGLYCOSIDES FROM GLYCALS" ABSTRACT OF THE DISCLOSURE A process is provided for reacting 3,4,6-tri-O-acetyl-2- azido-2-deoxy-.beta.-D-galactopyranosyl chloride with an alcohol in the presenceof a promoter to produce 3,4,6-tri-O-acetyl-2-azido-2-deoxy-.alpha.-D- galactopyranosides. The 2-azido-2-deoxy glycosides can be reduced and deblocked to obtain the 2-amino-2-deoxy glycosides, which correspond to the terminal unit of the antigenic determinant for the human A blood group. Attachment of these glycosides to a solid support provides immunoabsorbents which efficiently and preferentially absorb anti-A antibodies from bloo~ plasma.

367511

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