Synthesis of 2-amino-2-deoxyglycoses and 2-amino-2-...

Details Synthesis of 2-amino-2-deoxyglycoses and 2-amino-2-... Synthesis of 2-amino-2-deoxyglycoses and 2-amino-2-...

C - Chemistry, Metallurgy

07

H

260/227

C07H 5/04 (2006.01) C07H 3/06 (2006.01) C07H 5/06 (2006.01) C07H 11/02 (2006.01) C07H 13/08 (2006.01) C07H 15/04 (2006.01)

Patent

CA 1105011

"SYNTHESIS OF 2-AMINO-2-DEOXYGLYCOSES AND 2-AMINO-2-DEOXYGLYCOSIDES FROM GLYCALS" ABSTRACT OF THE DISCLOSURE O-acetylated glycals react with ceric ammonium nitrate in the presence of sodium azide to provide, in good yield, O-acetylated 2-azido-2-deoxy glycosyl nitrates. These nitrates can be used to prepare 2-amino-2-deoxy sugars, such as D-galactosamine and lactosamine. The O-acetylated 2-azido-2-deoxy glycosyl nitrates can alternately be con- verted to O-acetylated 2-azido-2-deoxy glycosyl halides which are useful in the preparation of O-acetylated 2-azido-2-deoxy glycosides, which in turn can be reduced to 2-amino-2-deoxy glycosides. Of particular interest are the syntheses of 2-amino-2-deoxy glycosides which correspond to the terminal units of the antigenic determinant for the human A blood group. Attachment of these glycosides to a solid support provides immunoabsorbents which efficiently and preferentially absorb anti-A antibodies from blood plasma.

300489

Affiliated with

Also associated with

Rating

Synthesis of 2-amino-2-deoxyglycoses and 2-amino-2-... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Synthesis of 2-amino-2-deoxyglycoses and 2-amino-2-..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthesis of 2-amino-2-deoxyglycoses and 2-amino-2-... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-933552