Synthesis of 2-aralkoxyadenosines and 2-alkoxyadenosines

C - Chemistry – Metallurgy – 07 – H

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C07H 19/167 (2006.01) C07H 19/16 (2006.01) C07H 19/173 (2006.01)

Patent

CA 2465264

The invention provides new methods for synthesis of 2-aralkyloxyadenosines and 2-alkoxyadenosines. The invention is particularly useful for synthesis of 2-[2- (4-chlorophenyl)ethoxy]adenosine. Preferred methods of the invention include activating a guanosine compound followed by hydrolysis; alkylating the hydrolyzed compound with subsequent amination to provide a 2- aralkyloxyadenosine or a 2-alkoxyadenosine compound.

L'invention concerne des nouveaux procédés de synthèse de 2-aralkyloxyadénosines et de 2-alcoxyadénosines. L'invention s'avère particulièrement utile pour la synthèse de 2-[2-(4-chlorophényle)éthoxy]adénosine. Des procédés préférés de l'invention comprennent les étapes consistant: à procéder à l'activation d'un composé guanosine suivie d'une hydrolyse; et à alkyler le composé hydrolysé au moyen d'une amination subséquente afin que soit obtenu un composé 2-aralkyloxyadénosine ou un composé 2-alcoxyadénosine.

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