Synthesis of 2-cyanoaziridine-1-carboxamide

C - Chemistry – Metallurgy – 07 – D

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C07D 203/16 (2006.01) C07D 203/20 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2468542

The present invention provides a process for producing an aziridine-1- carboxamide of the formula: (I) from an aziridine of the formula: (II) and an isocyanate of the formula R5-N=C=O, where R1~, R2~, R3~, R4~ and R5~ are those defined herein. In addition, the present invention also provides a process for producing a 4-imino-1,3-diazabicyclo[3.1.0]-hexan-2-one of the formula: (a) from the aziridine-1-carboxamide of Formula (I).

L'invention concerne un procédé de production d'une aziridine-1-carboxamide de la formule (I) à partir d'une aziridine de la formule (II) et d'un isocyanate de la formule R5-N=C=O, R1, R2, R3, R4 et R5 étant comme définis dans le descriptif. En outre, l'invention concerne un procédé de production d'un 4-imino-1,3-diazabicyclo[3.1.0]-hexan-2-one de la formule: (a) à partir de l'aziridine-1-carboxamide de la formule (I).

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