C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 1/08 (2006.01) A61K 31/7052 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) C07H 1/06 (2006.01) C07H 19/06 (2006.01) C07H 19/16 (2006.01) C12N 15/10 (2006.01)
Patent
CA 2391279
This invention provides processes for the preparation of compounds having structure (A) wherein X and Y are same or different, and H, OH, OR, SH, SR, NH2, NHR', or NR'R"; Z is H, F, Cl, Br, I, CN or NH2. R is hydrogen, halogen, lower alkyl of C1-C6 or aralkyl, NO2, NH2, NHR', NR'R", OH, OR, SH, SR, CN, CONH2, CSNH2, CO2H, CO2R', CH2CO2H, CH2CO2R', CH=CHR, CH2CH=CHR, or C=CR. R' and R" are same or different, and lower alkyl of C1-C6. R13 is hydrogen, alkyl, acyl, phosphate (monophosphate, diphosphate, triphosphate, or stabilized phosphate) or silyl.
L'invention concerne des techniques de préparation de composés dont la structure est représentée par la formule (I). Dans cette formule, X et Y sont identiques ou différents, et représentent H, OH, OR, SH, SR, NH¿2?, NHR', ou NR'R"; Z représente H, F, Cl, Br, I, CN ou NH¿2?; R représente hydrogène, halogène, alkyle inférieur C¿1?-C¿6? ou aralkyle, NO¿2?, NH¿2?, NHR', NR'R", OH, OR, SH, SR, CN CONH¿2?, CSNH¿2?, CO¿2?H, CO¿2?R', CH¿2?CO¿2?H, CH¿2?CO¿2?R', CH=CHR, CH¿2?CH=CHR, ou C=CR; R' et R" sont identiques ou différents, et représentent alkyle inférieur C¿1?-C¿6?; R?13¿ représente hydrogène, alkyle, acyle, phosphate (monophosphate, diphosphate, triphosphate, ou phosphate stabilisé) ou silyle.
Choi Woo-Baeg
Watanabe Kyoichi A.
Mbm Intellectual Property Law Llp
Pharmasset Inc.
Pharmasset Limited
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