Synthesis of 2-isopropylamino pyrimidine

C - Chemistry – Metallurgy – 07 – D

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C07D 239/42 (2006.01) C07D 239/38 (2006.01)

Patent

CA 1132563

A B S T R A C T The present invention provides a process for the synthesis of 2-isopropylamino-pyrimidine by aminolysis of 2-methylsulphonyl-pyrimidine using isopropylamine. The aminolysis is effected, according to the present invention, by refluxing isopropylamine and 2-methylsulphonyl- pyrimidine in the absence of a solvent. Using this technique, the 2-isopropylamino-pyrimidine has been obtained in a substantially quantitative yield.

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