Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one

C - Chemistry – Metallurgy – 07 – D

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C07D 309/32 (2006.01) C07C 67/30 (2006.01) C07C 67/31 (2006.01) C07D 305/12 (2006.01) C07F 3/02 (2006.01)

Patent

CA 2397232

The present invention relates to a novel process for producing a .delta.-lactone of the formula (I) using an acyl halide of the formula (1) wherein R1, R2, R3 and X are described herein, as well as novel intermediates. In particular, the present invention relates to a process for enantioselectively producing the (R)-.delta.-lactone.

L'invention concerne un nouveau procédé de préparation de .delta.-lactone de la formule (I), à l'aide d'halogénure d'acyle de la formule (1), où R?1¿, R?2¿, R?3¿ et X ont la signification mentionnée dans la description. L'invention concerne également de nouveaux intermédiaires. L'invention concerne notamment un procédé de préparation de (R)-.delta.-lactone par énantiosélectivité.

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