Synthesis of 3-amino-thalidomide and its enantiomers

Details Synthesis of 3-amino-thalidomide and its enantiomers Synthesis of 3-amino-thalidomide and its enantiomers

A - Human Necessities

61

K

A61K 31/4035 (2006.01) A61K 31/454 (2006.01) A61P 9/00 (2006.01)

Patent

CA 2430669

The invention provides new and useful analogs of 3-amino-thalidomide. These analogs include S(-)-3-amino-thalidomide and R(+)-3-amino-thalidomide. The invention also provides processes for making these analogs. Further, the invention provides methods for inhibiting angiogenesis and treating angiogenesis-associated diseases, including cancer and macular degeneration, by administering these compounds.

L'invention concerne de nouveaux analogues utiles de 3-amino-thalidomide. Ces analogues comprennent S(-)-3-amino-thalidomide et R(+)-3-amino-thalidomide. Elle concerne également des procédés servant à préparer ces analogues. Elle concerne, de plus, des procédés servant à inhiber l'angiogenèse et à traiter des maladies associées à l'angiogenèse, y compris le cancer et la dégénérescence maculaire, par administration de ces composés.

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