Synthesis of 4-¬(5-substituted or unsubstituted...

Details Synthesis of 4-¬(5-substituted or unsubstituted... Synthesis of 4-¬(5-substituted or unsubstituted...

C - Chemistry, Metallurgy

07

D

C07D 231/12 (2006.01)

Patent

CA 2360354

This invention encompasses a novel process for synthesizing the compound represented by formula (I) or a salt, hydrate or solvate thereof, wherein A represents H, halo, or methyl, and B represents CH3, CH2F, CHF2 OR CF3, comprising reacting a compound of formula (II) with a compound of formula (III) or a salt or hydrate thereof, in an amide solvent at a controlled temperature to produce a compound of formula (I). These compounds are useful as non-steroidal anti-inflammatory agents.

La présente invention concerne un nouveau procédé de synthèse du composé correspondant à la formule (I), ou d'un sel, d'un hydrate ou d'un solvate dudit composé. Dans la formule (I), A représente H, halo ou méthyle, et B représente CH¿3?, CH¿2?F, CHF¿2? ou CF¿3?. Ledit procédé comprend la réaction d'un composé de formule (II) avec un composé de formule (III), ou un sel ou un hydrate de ce composé, dans un solvant amide, à une température contrôlée, pour produire un composé de formule (I). Ces composés sont utilisés en tant qu'agents anti-inflammatoires non stéroïdiens.

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