Synthesis of 4-amino-1,2-hydrocarbyl pyrazolidines via...

Details Synthesis of 4-amino-1,2-hydrocarbyl pyrazolidines via... Synthesis of 4-amino-1,2-hydrocarbyl pyrazolidines via...

C - Chemistry, Metallurgy

07

D

260/315.5

C07D 231/04 (2006.01)

Patent

CA 1164001

AHR-390 17 ABSTRACT OF THE INVENTION SYNTHESIS OF 4-AMINO-1,2-HYDROCARBYL PYRAZOLIDINES VIA 4-NITRO ANALOGS 4-Nitro-1,2-hydrocarbyl pyrazolidines are prepared by a novel route from 1,2-disubstituted hydrazines and 1,3-di-(secondary amino)-2-nitropropanes and reduced to the corresponding 4-amino-1,2-hydrocarbyl pyrazolidines, which latter compounds are intermediates in the preparation of certain pharmaceutical benzamides. The novel 4-nitro-1,2-hydrocarbyl pyrazolidines have the formula: Image wherein R1 and R2 are selected from loweralkyl, lowercyclo- alkyl or phenyl-loweralkyl and may be the same or different.

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