C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/58 (2006.01)
Patent
CA 2692001
Disclosed herein are methods for synthesizing N-(4-fluorobenzy I)-N-(I - methylpiperidin-4-yl)-N'-(4-(2-methyl- propyloxy)phenylmethyl)carbamide. Also disclosed herein is the hemi-tartrate salt of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4- yl)-N'-(4-(2- methylpropyloxy)-phenylmethyl)carbamide and methods for obtaining the salt. Further disclosed are various crystalline forms of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N'- (4-(2- methylpropyloxy)phenylmethyl)carbamide and its hemi-tartrate salt including various polymorphs and solvates.
L'invention concerne des procédés de synthèse de N-(4-fluorobenzyl)-N-(L-méthylpypéridin-4-yl)-N'-(4-2-méthylpropyloxy)phénylméthyl)carbamide. Le sel d'hémitartrate de N-(4-fluorobenzyl)-N-(L-méthylpypéridin-4-yl)-N'-(4-2-méthylpropyloxy)phénylméthyl)carbamide et des procédés pour obtenir le sel sont également décrits. Diverses formes cristallines de N-(4-fluorobenzyl)-N-(L-méthylpypéridin-4-yl)-N'-(4-2-méthylpropyloxy)phénylméthyl)carbamide et de son sel d'hémitartrate sont en outre décrites, y compris divers polymorphes et solvats.
Schlienger Nathalie
Thygesen Mikkel Boas
Tolf Bo-Ragmar
Acadia Pharmaceuticals Inc.
Osler Hoskin & Harcourt Llp
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