Synthesis of 6-methylene derivatives of...

Details Synthesis of 6-methylene derivatives of... Synthesis of 6-methylene derivatives of...

C - Chemistry, Metallurgy

07

J

260/39

C07J 1/00 (2006.01) C07J 75/00 (2006.01)

Patent

CA 1319680

A B S T R A C T The invention relates to a new process for the preparation of known aromatase inhibitors of the following formula (I) Image (I) wherein each of R1 and R3, independently, is hydrogen or C1-C6 alkyl; R2 is hydrogen, halogen or C1-C6 alkyl; and R4 is hydrogen or fluorine; the process comprising submitting to Mannich reaction a com- pound of formula (II) Image (II) wherein R1, R2, R3 and R4 are as defined above and R is a lower alkyl group, and then dehydrogenating the respective 6-methylene-3-oxo-.DELTA.4 -steroid derivative thus obtained, by methods known per se.

589067

Affiliated with

Also associated with

Rating

Synthesis of 6-methylene derivatives of... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Synthesis of 6-methylene derivatives of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthesis of 6-methylene derivatives of... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1206940