Synthesis of a benzoxazinone

Details Synthesis of a benzoxazinone Synthesis of a benzoxazinone

C - Chemistry, Metallurgy

07

D

C07D 265/18 (2006.01)

Patent

CA 2578966

The present invention provides novel methods for the synthesis of (S)-6-chloro- 4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one of formula (III) which is useful as a human immunodeficiency virus (HIV) reverse transcriptase inhibitor.

L'invention porte sur de nouvelles méthodes de synthèse de (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one représenté par la formule (III), utile en tant qu'inhibiteur de la transcriptase inverse du virus de l''immunodéficience humaine (VIH).

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