Synthesis of a bis (sulfonyl) ether from sulfonic acid via...

C - Chemistry – Metallurgy – 07 – C

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C07C 303/00 (2006.01) C07C 303/26 (2006.01) C07C 303/44 (2006.01)

Patent

CA 2674873

The present invention provides a method of preparing a sulfonyl ether comprising the steps of: v) reacting a sulfonic acid with an anhydride, under continuous vacuum distillation conditions, to form a carboxysulfonate; vi) reacting the carboxysulfonate with an optionally substituted cycloalkane ring containing at least 3 heteroatoms to form a sulfonyl ether pre-mix comprising a sulfonyl ether and at least two additional reaction products each containing at least one ether linkage; vii) subjecting the pre-mix to continuous vacuum distillation conditions to remove at least some of the additional reaction products from the sulfonyl ether pre-mix to provide a crude sulfonyl ether product; and viii) purifying the crude sulfonyl ether product.

La présente invention concerne un procédé de préparation d'un éther de sulfonyle, consistant v) à mettre en réaction un acide sulfonique avec un anhydride dans des conditions de distillation sous vide en continu pour former un carboxysulfonate; vi) à mettre en réaction le carboxysulfonate avec un noyau de cycloalcane éventuellement substitué contenant au moins 3 hétéroatomes pour former un pré-mélange d'éther de sulfonyle comprenant un éther de sulfonyle et au moins deux produits de réaction supplémentaires contenant chacun au moins une liaison éther; vii) à soumettre le pré-mélange à des conditions de distillation sous vide en continu pour éliminer au moins certains des produits de réaction supplémentaires du pré-mélange d'éther de sulfonyle afin d'obtenir un produit d'éther de sulfonyle brut, et viii) à purifier le produit d'éther de sulfonyle brut.

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