Synthesis of acyclic, terpene alcohols

C - Chemistry – Metallurgy – 07 – C

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260/637, 260/635

C07C 31/02 (2006.01) C07C 31/18 (2006.01) C07C 43/04 (2006.01)

Patent

CA 1084952

ABSTRACT OF THE DISCLOSURE Shown is a process for the synthesis of acyclic, terpene alcohols, such as 3,7-dimethyloctan-1-ol and 7- substituted hydroxy or ethoxy deriva?ives thereof, wherein 3-methylbut-1-yn or the 3-substituted hydroxy or ether deriva- tive thereof is coupled with a C5 coupling reagent having the configuration Image X being a leaving group such as chlorido, bromide, iodide, tosylate and mesylate; R being Image or OR', R' being a lower alkyl up to 5 carbon atoms, phenyl, substituted phenyl up to 10 carbon atoms, cycloalkyl or aralkyl up to 10 carbon atoms, followed by hydrogenation and saponification or deetherifica- tion.

286154

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