Synthesis of acyloxyalkyl carbamate prodrugs and...

Details Synthesis of acyloxyalkyl carbamate prodrugs and... Synthesis of acyloxyalkyl carbamate prodrugs and...

C - Chemistry, Metallurgy

07

D

C07D 207/40 (2006.01)

Patent

CA 2551859

Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.

Procédés de synthèse de carbamates de 1-(acyloxy)-alkyle, en particulier de promédicaments à base de carbamate de 1-(acyloxy)-alkyle de médicaments contenant de l'amine du type primaire ou secondaire. L'invention concerne également des procédés de synthèse de carbonates de 1-(acyloxy)-alkyle N-hydroxysuccinimidyle, qui sont des intermédiaires utiles pour la synthèse de carbamates de 1-(acyloxy)-alkyle.?¿

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