Synthesis of anastrozole and purification of one of its...

C - Chemistry – Metallurgy – 07 – C

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C07C 253/34 (2006.01) A61K 31/4196 (2006.01) A61P 35/00 (2006.01) C07C 255/33 (2006.01) C07D 249/08 (2006.01)

Patent

CA 2606958

The invention is directed to processes for purifying the Anastrozole intermediate, 3,5-bis(2-cyanoisopropyl)toluene, processes for producing Anastrozole, processes for preparing Anastrozole pharmaceutical compositions, and Anastrozole and Anastrozole pharmaceutical compositions prepared with the processes of the invention.

La présente invention concerne des procédés de purification du 3,5-bis(2-cyanoisopropyl)toluène, intermédiaire de l'Anastrozole, des procédés de production de l'Anastrozole, des procédés d'élaboration de préparations pharmaceutiques contenant de l'Anastrozole, ainsi que de l'Anastrozole et des préparations pharmaceutiques contenant de l'Anastrozole préparés par le biais des procédés selon l'invention.

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