Synthesis of azetidinones

C - Chemistry – Metallurgy – 07 – D

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260/111, 260/335

C07D 205/09 (2006.01) C07D 499/00 (2006.01) C07D 499/88 (2006.01) C07F 7/10 (2006.01) C07F 7/18 (2006.01)

Patent

CA 1299172

ABSTRACT A process for producing a compound having the formula Image I wherein Pr is hydrogen or a hydroxy protecting group and Pr1 is a carboxy protecting group, comprising reacting a compound of the formula Image 5 wherein Pr is as previously defined, with a compound having the formula Pr1-OH, wherein Pr1 is as previously defined and either mineral acid or a silver salt of an organic base, and reacting the product so produced with a compound having the formula: Image wherein L is a leaving group. Three reaction schemes are disclosed as well as novel intermediate compounds.

542505

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