C - Chemistry – Metallurgy – 07 – B
Patent
C - Chemistry, Metallurgy
07
B
C07B 43/06 (2006.01) B01J 19/00 (2006.01) C07B 61/00 (2006.01) C07C 235/12 (2006.01) C07D 203/12 (2006.01) C07D 303/46 (2006.01) C07D 405/12 (2006.01) C07K 1/04 (2006.01) C07K 2/00 (2006.01) G01N 33/532 (2006.01) G01N 33/543 (2006.01) G01N 33/552 (2006.01) G01N 33/553 (2006.01)
Patent
CA 2167391
The present invention relates to an array of compounds having a common core structure wherein the compounds of the array comprise the products of a multiple component combinatorial array synthesis having at least three components. The present invention also relates to the method of synthesizing that array. A further embodiment of the present invention relates to the use of solid phase synthesis to synthesize the combinatorial array of compounds. The present invention also relates to a method of creating a combinatorial array of compounds with a common core structure by identifying the desired core structure, identifying an MCCA reaction capable of generating that core structure, followed by preparing an array of compounds using the identified MCCA reaction according to the aforementioned method. The present invention also relates to a method for conducting in vitro assays of biological material using the combinatorial arrays of the present invention.
Agencement de composés ayant une structure centrale commune, dans lequel lesdits composés de l'agencement comprennent les produits d'une synthèse d'agencements combinatoires à constituants multiples (MCCA) ayant au moins trois constituants. La présente invention concerne également le procédé permettant de réaliser la synthèse de cet agencement. Un autre mode de réalisation concerne l'utilisation de la synthèse en phase solide pour synthétiser lesdits agencements combinatoires de composés. La présente invention concerne également un procédé de création d'un agencement combinatoire de composés ayant une structure centrale commune, qui consiste à identifier la structure centrale désirée, à identifier une réaction MCCA capable d'engendrer ladite structure centrale, puis à préparer un agencement de composés à l'aide de la réaction MCCA identifiée selon le procédé susmentionné. La présente invention concerne en outre un procédé permettant de faire des analyses in vitro de matériau biologique à l'aide des agencements combinatoires de la présente invention.
Osler Hoskin & Harcourt Llp
The Regents Of The University Of California
LandOfFree
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