Synthesis of combretastatin a-4 prodrugs and trans-isomers...

Details Synthesis of combretastatin a-4 prodrugs and trans-isomers... Synthesis of combretastatin a-4 prodrugs and trans-isomers...

C - Chemistry, Metallurgy

07

F

C07F 9/12 (2006.01) C07F 9/09 (2006.01)

Patent

CA 2314238

Combretastatin A-4 has been previously selected for pre-clinical development as antineoplastic agents. However, it is essentially insoluble in water. New water soluble derivatives of combretastatin A-4 and its qualified analogs have been discovered and synthesized through a multistage process using other derivatives of combretastatin A-4 as intermediates. These water soluble derivatives are herein denominated as "Combretastatin A-4 Prodrugs".

Selon cette invention, on a déjà utilisé la Combrestatine A-4 pour le développement préclinique, en tant qu'agent antinéoplasique; cependant, elle est généralement insoluble dans l'eau. On a découvert et synthétisé de nouveaux dérivés hydrosolubles de la Combrestatine A-4, ainsi que leurs analogues agréés, en passant par un procédé à plusieurs étapes et en utilisant comme intermédiaires d'autres dérivés de la Combrestatine A-4. Ces dérivés hydrosolubles sont désignés dans l'invention comme des "promédicaments à base de Combrestatine A-4".

Affiliated with

Also associated with

Rating

Synthesis of combretastatin a-4 prodrugs and trans-isomers... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Synthesis of combretastatin a-4 prodrugs and trans-isomers..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthesis of combretastatin a-4 prodrugs and trans-isomers... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1579384