Synthesis of encoded polymers

Details Synthesis of encoded polymers Synthesis of encoded polymers

C - Chemistry, Metallurgy

12

N

C12N 15/10 (2006.01) C07H 21/00 (2006.01) C07K 1/04 (2006.01) C07K 2/00 (2006.01) C07K 17/00 (2006.01) C12P 19/34 (2006.01) C12Q 1/68 (2006.01) G01N 33/543 (2006.01)

Patent

CA 2151473

Conjugates and methods of producing the conjugates and mixtures thereof are disclosed. Conjugates are comprised of an active polymer made up of monomer units selected from the group consisting of the monomer units of peptides and/or peptoids, and an encoding polymer comprised of encoding monomers wherein the encoding polymer corresponds to the active polymer, and a coupling moiety covalently coupled to the active polymer and the encoding polymer. In accordance with the synthesis methodology, mixtures of large numbers of conjugates are produced by providing a coupling moiety and covalent binding it to an active monomer and an encoding monomer. Additional monomer units are added to the active monomer to create an active polymer and additional monomer units are added to the encoding monomer to produce an encoding polymer until the desired length is reached for the active polymer. Mixtures of conjugates attached to support bases can be used to assay a sample. The sample is brought into contact with the conjugates and a determination is made with respect to which active proteins bind to receptor sites within the sample. When active binding proteins are determined, the encoding polymer associated with the active polymer is sequenced, and by deduction, the sequence of the active polymer is determined.

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