Synthesis of epothilones and related analogs

Details Synthesis of epothilones and related analogs Synthesis of epothilones and related analogs

C - Chemistry, Metallurgy

07

D

C07D 417/06 (2006.01) A61P 35/00 (2006.01) C07C 17/093 (2006.01) C07C 17/16 (2006.01) C07C 45/29 (2006.01) C07C 47/277 (2006.01) C07D 275/06 (2006.01) C07D 277/24 (2006.01) C07D 277/30 (2006.01) C07D 313/00 (2006.01) C07D 493/04 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2425828

The present invention relates to methods for use in producing epothilones and analogs and derivatives thereof. A general method according to the present invention broadly comprises performing an aldol condensation of a first compound with a second compund thereby to form a third compound selected from the formulas (I) and (II) and stereoisomers thereof, and performing a macrolactonization of the third compound. The present invention also provides chemical compounds, and methods for producing such chemical compounds, that are useful in producing epothilones and analogs and derivatives thereof.

L'invention concerne des procédés utiles dans la production d'épothilones, et d'analogues et dérivés de ces composés. Un procédé général comporte les étapes consistant à mettre en oeuvre une aldolisation d'un premier composé et d'un deuxième composé pour former un troisième composé sélectionné, représenté par les formules (I) et (II) et leurs stéréo-isomères ; et à mettre en oeuvre une macrolactonisation du troisième composé. L'invention concerne aussi des composés chimiques et des procédés de production de ces composés, utiles dans la production d'épothilones et de leurs analogues et dérivés.

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